Born in Tokyo, Yuzuko Horigome began playing the piano at the tender age of 4 and took up violin at the age of 5. Her first violin teacher was Ryosaku Kubota, after which she further developed her talent under the expert tutorship of Toshiya Eto, at the Toho Gakuen Academy.

In 1980, Horigome won the First Great Prize at the Queen Elisabeth Competition in Brussels, heralding the beginning of a hugely successful international career. Since then she has toured the world playing under the direction of such musical luminaries as Erich Leinsdorf, Sándor Végh, Herbert Blomstedt, André Prévin, Claudio Abbado, Seiji Ozawa, Iván Fischer, Riccardo Chailly, Simon Rattle and many others.

She has also appeared as a soloist with the world's greatest orchestras, including such the London Symphony, Berliner Philharmoniker, Wiener Symphoniker, Amsterdam Concertgebouw, Tonhalle Orchester Zürich, Scala di Milano, Czech Philharmonic, St Petersburg Philharmonic, Camerata Salzburg, New York Philharmonic, Boston Symphony, Philadelphia Orchestra, Chicago Symphony, Los Angeles Philharmonic, Montreal Symphony, New Japan, NHK Symphony, among others.